Pathology of the human spinal ganglia in varicella-zoster virus infection
Identifieur interne : 003A36 ( Main/Exploration ); précédent : 003A35; suivant : 003A37Pathology of the human spinal ganglia in varicella-zoster virus infection
Auteurs : Kazuo Nagashima [Japon] ; Masaki Nakazawa [Japon] ; Hisako Endo [Japon] ; Takeshi Kurata [Japon] ; Yuzo Aoyama [Japon]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1975-06-01.
English descriptors
- KwdEn :
- Teeft :
- Aeta neuropath, Capsular cells, Electron microscopy, Ganglion, Herpes, Herpes simplex virus, Herpes zoster, Inclusion, Inclusion bodies, Intranuclear, Multiple sclerosis, Nagashima, Naked particles, Neuron, Nuclear membrane, Satellite cells, Sclerosis, Simplex, Skin eruption, Skin lesions, Spinal, Spinal ganglia, Spinal ganglion, Varicella, Varicella case, Varieella, Viral, Virus infection, Virus particles, Zoster.
Abstract
Summary: Spinal ganglia from a patient who died on the 6th day of varicella infection were examined by immunofluorescence and electron microscopy, and were compared with spinal ganglia from a patient dying on the 17th day of herpes zoster infection. In herpes zoster, typical intranuclear inclusion bodies were found in neurons, satellite cells and fibroblast-like cells of the ganglia, which contained numerous naked virus particles. In varicella, few changes were found by light microscopy but viral antigen was detected in a few neurons and satellite cells by immunofluorescence. Electron microscopy revealed scattered virus particles near the nuclear membrane of a neuron, satellite cells and capsular cells and enveloped particles in the cytoplasma of satellite cells. The particles in the nuclei were mostly naked virions with specific crescent-like inner-nuclear structure; those in the cytoplasm had complete and incomplete envelopes and showed pleomorphism. A “virus-like” intranuclear filament found in mononuclear cells in herpes zoster and a “plexiform vermicellar array” found in the nuclei of neurons in varicella are at present considered to be non-specific nuclear changes caused probably by viral infections.
Url:
DOI: 10.1007/BF00687537
Affiliations:
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lesions</term><term>Spinal</term><term>Spinal ganglia</term><term>Spinal ganglion</term><term>Varicella</term><term>Varicella case</term><term>Varieella</term><term>Viral</term><term>Virus infection</term><term>Virus particles</term><term>Zoster</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Spinal ganglia from a patient who died on the 6th day of varicella infection were examined by immunofluorescence and electron microscopy, and were compared with spinal ganglia from a patient dying on the 17th day of herpes zoster infection. In herpes zoster, typical intranuclear inclusion bodies were found in neurons, satellite cells and fibroblast-like cells of the ganglia, which contained numerous naked virus particles. In varicella, few changes were found by light microscopy but viral antigen was detected in a few neurons and satellite cells by immunofluorescence. Electron microscopy revealed scattered virus particles near the nuclear membrane of a neuron, satellite cells and capsular cells and enveloped particles in the cytoplasma of satellite cells. The particles in the nuclei were mostly naked virions with specific crescent-like inner-nuclear structure; those in the cytoplasm had complete and incomplete envelopes and showed pleomorphism. A “virus-like” intranuclear filament found in mononuclear cells in herpes zoster and a “plexiform vermicellar array” found in the nuclei of neurons in varicella are at present considered to be non-specific nuclear changes caused probably by viral infections.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement><orgName><li>Université de Tokyo</li></orgName></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Nagashima, Kazuo" sort="Nagashima, Kazuo" uniqKey="Nagashima K" first="Kazuo" last="Nagashima">Kazuo Nagashima</name></region><name sortKey="Aoyama, Yuzo" sort="Aoyama, Yuzo" uniqKey="Aoyama Y" first="Yuzo" last="Aoyama">Yuzo Aoyama</name><name sortKey="Endo, Hisako" sort="Endo, Hisako" uniqKey="Endo H" first="Hisako" last="Endo">Hisako Endo</name><name sortKey="Kurata, Takeshi" sort="Kurata, Takeshi" uniqKey="Kurata T" first="Takeshi" last="Kurata">Takeshi Kurata</name><name sortKey="Nakazawa, Masaki" sort="Nakazawa, Masaki" uniqKey="Nakazawa M" first="Masaki" last="Nakazawa">Masaki Nakazawa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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